IV. INTRAABDOMINAL OR PELVIC INFECTIONS
• Community-Acquired/Normal Host: Ceftriaxone 1gm q 24h plus Flagyl 500mg IV q 12h; OR, Cipro 400mg q 12h plus Flagyl 500mg IV q 24h; OR, Ertapenem (Invanz) 1g q 24h. Each option + Tobramycin (ODA x 1-3 days).
• Health Care Associated/Compromised Host: Zosyn 4.5gm q 8h plus Fluconazole 400mg q 24h; OR, Cipro 400mg q 12h plus Unasyn 3gm q 6h plus Fluconazole 400mg q 24h. Both options + Tobramycin (ODA x 1-3 days)
• Penicillin Allergy (Type I): Cipro 400mg q 12h or Aztreonam 2gm q 8h, PLUS Cleocin 600mg q 8h; + Fluconazole 400mg q 24h; + Tobramycin (ODA x 1-3 days).
• Streamlining: change to narrower-spectrum agent(s) based on microbiology results.
• Switch Therapy: Cipro 500mg po BID or Bactrim DS BID; PLUS, Flagyl 500mg po q 12h or Cleocin 300mg po QID or Augmentin 875mg BID.