Suggested Empiric Antimicrobial Agents of Choice (7th Edition) Wausau Hospital 2006-2008 Infectious Disease Section & Pharmacy and Therapeutics Committee ©WAB/2006

II. COMMUNITY-ACQUIRED PNEUMONIA (CAP)
(First doses within 4 hours of admission)
• Non-ICU: OPTION 1- Ceftriaxone 1gm q 24h,
PLUS Azithromycin 500mg po/IV q 24h. OPTION 2- Moxifloxacin (Avelox) 400mg IV/po
q 24h (as monotherapy).
• ICU: Ceftriaxone 1gm q 24h PLUS, Moxifloxacin (Avelox) 400mg IV q 24h.
• Possible Pseudomonas (history of bronchiectasis, recent antibiotics, recent hospitalization): Cefepime 2gm q 12h PLUS Cipro 400mg q 8hr.
• Streamlining: change to narrower-spectrum agent(s) based on microbiology results.
• Switch Therapy: after "improvement" on IV (resolving symptoms, temperature, & WBC): Moxifloxacin 400mg po q 24h x 7 days; OR, Azithromycin 500mg po q 24h x 5 days; OR, Telithromycin (Ketek) 800mg po q 24h x 7d.