"SEPSIS" OF UNKNOWN ETIOLOGY
• Community-Acquired/Normal Host: Tobramycin (ODA) or Cipro 400mg q 12h, PLUS Ceftriaxone 1gm q 24h, PLUS Vancomycin 1-1.5gm q 12-24h (trough 10-15 ug/ml: D/C Vancomycin if cultures negative for MRSA/MRSE at 48 hr).
• Health Care-Associated/Compromised Host: Tobramycin (ODA) or Cipro 400mg q 12h, PLUS Zosyn 4.5gm q8h or Cefepime 2gm q 12h, PLUS Vancomycin 1-1.5gm q 12-24h (as above).
• Streamlining: change to narrower spectrum agent(s) based on microbiology results.